Endocrine Abstracts

Gene delivery to the CNS is undermined by the lack of suitable vectors capable of delivering genes with sufficient specificity, efficacy and safety. In previous studies we have shown that bacteriophage particles, which lack tropism for mammalian cells, can be genetically modified to display specific ligands that allow binding, internalisation and cell transduction of receptor-bearing target cells. Moreover, phage particles can be forced to evolve using combinatorial techniques...

Gene delivery to the CNS is undermined by the lack of suitable vectors capable of delivering genes with sufficient specificity, efficacy and safety. In previous studies we have shown that bacteriophage particles, which lack tropism for mammalian cells, can be genetically modified to display specific ligands that allow binding, internalisation and cell transduction of receptor-bearing target cells. Moreover, phage particles can be forced to evolve using combinatorial techniques...

A small subset of genes in the human genome encode peptides that have intrinsic therapeutic value. These genes, collectively known as the "theratome", most often encode ligands and are of particular interest to endocrinology. The genes encoding growth hormone, somatostatin, erythropoeitin, neuropeptides, placental and pituitary hormones are all examples of the theratome. Unfortunately, the sequences encoding many ligands are not always detectable within the sequences of their ...